Oni we dwóch podkładają głosy pod większość postaci:
Matt Stone:
* Kyle and his father, Gerald
* Kenny and his father, Stuart
* Jimbo Kern
* Jesus
* Butters
* Saddam Hussein
* Big Gay Al
* Pip
* Terrance
* Tweek
* Jimmy's father (Richard Vulmer)
* Priest Maxi
* Mr. Adler the shop teacher
* Various others
Trey Parker:
* Stan , his father, Randy Marsh and his grandfather, Marvin Marsh
* Eric Cartman
* Clyde Donovan
* Craig and his parents
* Kevin
* Herbert/Janet Garrison
* Stephen Stotch
* Mr. Hankey
* God
* Santa Claus
* Mr. Mackey
* Officer Barbrady
* Ms. Choksondik
* Timmy
* Jimmy Vulmer
* Tuong Lu Kim
* Dougie
* Phillip
* Satan
* Brian Boitano
* Dog Poo
* and other characters
* singing vocals
Do tego tylko dwie aktorki podkładające głosy pod wszystkie postaci żeńskie i Adrien Beard (Token Black), Vernon Chatman (Towelie), Jennifer Howell (Bebe Stevens), and John Hansen (Mr. Slave)